Scientific evidence

Peer-reviewed studies

Published research supporting Fagron bases — compatibility, stability and clinical data, organized by the base each study was performed in.

12 studies published in peer-reviewed journals.

Oral vehicle compatibility

Beyond-use dating and API compatibility across the Fagron oral vehicle range, July 2026 edition.

View the compatibility table

Fagron Library

Browse the full Fagron scientific library for additional publications and technical literature.

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HRT Heavy

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International Journal of Pharmaceutical Compounding (Jan–Feb) · 2024

Compatibility of various hormones in Phytobase and HRT Heavy cream bases

Peer-reviewed compatibility assessment of estradiol, estriol, progesterone and testosterone compounded in Phytobase and HRT Heavy cream bases.

International Journal of Pharmaceutical Compounding (Jul–Aug) · 2024

Extended chemical and microbial stability of various hormones in Phytobase and HRT Heavy cream bases

Extended beyond-use-date data covering chemical assay and microbial stability of hormone preparations in Phytobase and HRT Heavy.

Kosmoscience — dermatologist-supervised clinical report · 2018

Dermal irritability, sensitization and phototoxicity evaluation of HRT Heavy

Clinical safety testing of HRT Heavy for primary and accumulated dermal irritation, sensitization, photosensitivity and phototoxicity.

In vitro transdermal study — Franz diffusion cells · 2019

Percutaneous absorption of progesterone in vitro using the EpiDerm skin model

Comparative percutaneous absorption of progesterone from HRT Botanical, HRT Heavy Anhydrous Base and PENCream over a 12-hour dose period.

Humco white paper · 2019

HRT Heavy transdermal studies — 5% progesterone

White paper summarizing percutaneous absorption pharmacokinetics of 5% progesterone compounded in HRT Heavy, measured by HPLC in human epidermal cultures.

Phytobase

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International Journal of Pharmaceutical Compounding (Jan–Feb) · 2024

Compatibility of various hormones in Phytobase and HRT Heavy cream bases

Peer-reviewed compatibility assessment of estradiol, estriol, progesterone and testosterone compounded in Phytobase and HRT Heavy cream bases.

International Journal of Pharmaceutical Compounding (Jul–Aug) · 2024

Extended chemical and microbial stability of various hormones in Phytobase and HRT Heavy cream bases

Extended beyond-use-date data covering chemical assay and microbial stability of hormone preparations in Phytobase and HRT Heavy.

In vitro transdermal study — Franz diffusion cells · 2019

Percutaneous absorption of progesterone in vitro using the EpiDerm skin model

Comparative percutaneous absorption of progesterone from HRT Botanical, HRT Heavy Anhydrous Base and PENCream over a 12-hour dose period.

PENCream

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In vitro transdermal study — Franz diffusion cells · 2019

Percutaneous absorption of progesterone in vitro using the EpiDerm skin model

Comparative percutaneous absorption of progesterone from HRT Botanical, HRT Heavy Anhydrous Base and PENCream over a 12-hour dose period.

Pentravan

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Fagron compiled study brochure · 2023

Pentravan — trusted science with proven results

Compiled permeation, stability and clinical study data supporting Pentravan and Pentravan Plus transdermal delivery.

Pentravan Plus

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Fagron compiled study brochure · 2023

Pentravan — trusted science with proven results

Compiled permeation, stability and clinical study data supporting Pentravan and Pentravan Plus transdermal delivery.

TrichoCream™

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Current Drug Delivery · 2025

Physicochemical compatibility of minoxidil and associations in TrichoConcept bases

Evaluates the physicochemical compatibility and stability of minoxidil and common associations compounded in TrichoConcept vehicles.

Scientia Pharmaceutica · 2022

Compatibility of different formulations in the TrichoConcept range

Compatibility assessment of multiple active combinations across the TrichoConcept hair and scalp bases.

Journal of Cosmetics, Dermatological Sciences and Applications · 2017

In vitro effects of the phytocomplex TrichoTech on human fibroblasts

In vitro investigation of the TrichoTech phytocomplex and its activity on human dermal fibroblasts.

Journal of Dermatological Research and Therapy · 2018

Resveratrol, blueberry, cranberry and raspberry in TrichoCond

Antioxidant actives characterized in the TrichoCond conditioning system for scalp and hair care.

TrichoFoam™

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Current Drug Delivery · 2025

Physicochemical compatibility of minoxidil and associations in TrichoConcept bases

Evaluates the physicochemical compatibility and stability of minoxidil and common associations compounded in TrichoConcept vehicles.

Scientia Pharmaceutica · 2022

Compatibility of different formulations in the TrichoConcept range

Compatibility assessment of multiple active combinations across the TrichoConcept hair and scalp bases.

Journal of Cosmetics, Dermatological Sciences and Applications · 2017

In vitro effects of the phytocomplex TrichoTech on human fibroblasts

In vitro investigation of the TrichoTech phytocomplex and its activity on human dermal fibroblasts.

Journal of Dermatological Research and Therapy · 2018

Resveratrol, blueberry, cranberry and raspberry in TrichoCond

Antioxidant actives characterized in the TrichoCond conditioning system for scalp and hair care.

Scientia Pharmaceutica · 2023

Compounded hair solutions and foams containing minoxidil

Stability and performance data for compounded minoxidil solutions and foams prepared in TrichoConcept bases.

TrichoOil™

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Current Drug Delivery · 2025

Physicochemical compatibility of minoxidil and associations in TrichoConcept bases

Evaluates the physicochemical compatibility and stability of minoxidil and common associations compounded in TrichoConcept vehicles.

Scientia Pharmaceutica · 2022

Compatibility of different formulations in the TrichoConcept range

Compatibility assessment of multiple active combinations across the TrichoConcept hair and scalp bases.

Journal of Cosmetics, Dermatological Sciences and Applications · 2017

In vitro effects of the phytocomplex TrichoTech on human fibroblasts

In vitro investigation of the TrichoTech phytocomplex and its activity on human dermal fibroblasts.

Journal of Dermatological Research and Therapy · 2018

Resveratrol, blueberry, cranberry and raspberry in TrichoCond

Antioxidant actives characterized in the TrichoCond conditioning system for scalp and hair care.

TrichoSol™

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Current Drug Delivery · 2025

Physicochemical compatibility of minoxidil and associations in TrichoConcept bases

Evaluates the physicochemical compatibility and stability of minoxidil and common associations compounded in TrichoConcept vehicles.

Scientia Pharmaceutica · 2022

Compatibility of different formulations in the TrichoConcept range

Compatibility assessment of multiple active combinations across the TrichoConcept hair and scalp bases.

Journal of Cosmetics, Dermatological Sciences and Applications · 2017

In vitro effects of the phytocomplex TrichoTech on human fibroblasts

In vitro investigation of the TrichoTech phytocomplex and its activity on human dermal fibroblasts.

Journal of Dermatological Research and Therapy · 2018

Resveratrol, blueberry, cranberry and raspberry in TrichoCond

Antioxidant actives characterized in the TrichoCond conditioning system for scalp and hair care.

Scientia Pharmaceutica · 2023

Compounded hair solutions and foams containing minoxidil

Stability and performance data for compounded minoxidil solutions and foams prepared in TrichoConcept bases.

Journal of Cosmetology & Trichology · 2019

Effects of TrichoSol on increasing the anagen phase of volunteers

Clinical evaluation of TrichoSol and its effect on the anagen phase in study volunteers.

TrichoWash™

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Current Drug Delivery · 2025

Physicochemical compatibility of minoxidil and associations in TrichoConcept bases

Evaluates the physicochemical compatibility and stability of minoxidil and common associations compounded in TrichoConcept vehicles.

Scientia Pharmaceutica · 2022

Compatibility of different formulations in the TrichoConcept range

Compatibility assessment of multiple active combinations across the TrichoConcept hair and scalp bases.

Journal of Cosmetics, Dermatological Sciences and Applications · 2017

In vitro effects of the phytocomplex TrichoTech on human fibroblasts

In vitro investigation of the TrichoTech phytocomplex and its activity on human dermal fibroblasts.

Journal of Dermatological Research and Therapy · 2018

Resveratrol, blueberry, cranberry and raspberry in TrichoCond

Antioxidant actives characterized in the TrichoCond conditioning system for scalp and hair care.

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